ASS-100-Gentest

Acetylsalicylic acid (ASA) is a tried and tested active ingredient that belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs). It is a drug that is used in a variety of ways, primarily to relieve pain, reduce fever and inhibit inflammation. However, one of the most important and best-known uses of ASA is its blood-thinning effect, which helps to prevent cardiovascular disease. This effect makes ASA one of the most frequently prescribed preparations in cardiology.

ASA (also contained in Aspirin®) works by inhibiting the activity of cyclooxygenase enzymes (COX-1 and COX-2). These enzymes play a key role in the production of prostaglandins, which promote inflammation and pain, and thromboxane, which supports platelet aggregation. By inhibiting thromboxane, ASA helps to reduce platelet aggregation, thereby reducing the risk of blood clots and associated events such as heart attack or stroke.

The regular intake of low-dose ASA is particularly recommended for people with an increased cardiovascular risk. This applies in particular to people with existing cardiovascular disease or a predisposition to arterial occlusive disease. However, it is important to check the individual tolerability of ASA in advance, as the active ingredient does not have the same effect on everyone. Genetic differences, particularly in the GUCY1A3 gene, can significantly influence the effectiveness of ASA in thinning the blood and lead to side effects such as gastrointestinal bleeding.

Carrying out the ASA-100 genetic test before taking ASA on a long-term basis is therefore an important step. It makes it possible to better assess the efficacy and tolerability of ASA based on your individual genetic predisposition. With this knowledge, potential risks can be minimized and the therapy can be optimally tailored to your health needs in consultation with your treating physician.

Genetic markers are unchangeable characteristics in our DNA that accompany us from birth and remain the same until the end of our lives. These markers are specific sections of the genetic code that represent genetic variations or peculiarities. Their immutability is based on the stable structure of the DNA, which is stored in the cell nuclei and is passed on from generation to generation. While external factors, such as the environment or lifestyle, can influence gene activity (epigenetics), the genetic code itself remains unchanged.

The GUCY1A3 gene plays a central role in the cardiovascular system and influences how effectively ASA inhibits platelets – a key function of the drug in preventing blood clots.

By analyzing the gene, the test provides information on whether ASA works optimally for you or whether alternative treatment options should be considered. This allows side effects to be reduced and therapy to be optimized in a targeted manner – increasing safety and efficacy.

The ASS-100 genetic test is based on state-of-the-art genetic analysis methods that make it possible to analyze specific genetic markers precisely and reliably. The focus is on examining the GUCY1A3 gene mutation, an important genetic factor that can influence your response to acetylsalicylic acid (ASA) and your cardiovascular health.

To analyze these DNA regions, we use a combination of advanced genomics technology and proven molecular biology methods. Your genetic sample is obtained through a simple oral swab before being analyzed in a state-of-the-art laboratory in Germany. This laboratory works to the strictest quality standards and is certified to the international ISO 9001:2008 standard, guaranteeing the highest levels of safety and precision.

The central component of the test is targeted sequence analysis. This involves the use of technologies that have been specially developed for the detection of polymorphisms in DNA sequences, enabling the mutation in the GUCY1A3 gene to be detected with the highest accuracy. This genetic information is then processed in our analysis tools, which are compared with a database. This database includes the latest scientific findings, ensuring that your results are both scientifically sound and clinically relevant.

In addition, the analysis is accompanied by an interdisciplinary team of experts who combine genetic and medical expertise. The ASS-100 genetic test was developed in collaboration with leading molecular geneticists and scientists to ensure that the results are tailored to your individual needs.

The technology behind the ASS-100 genetic test follows the principle of personalized medicine. Invisible but unchangeable genetic variations determine how your body reacts to ASA – we use this information to provide you with customized recommendations for action. Each analysis is accompanied by a medical consultation to ensure that the results are interpreted correctly and are of direct benefit to your health decisions.

The ASS-100 genetic test not only provides you with reliable insights into your genetic predisposition, but also gives you access to a new, scientifically based health strategy.

The test result therefore provides valuable support for you and your doctor in order to develop a customized and safe therapy.

Not everyone reacts to ASA in the same way. Your genetic markers can influence how well the active ingredient works or whether there is an increased risk of side effects.

ASA is one of the most commonly used drugs for the prevention of cardiovascular disease, but its effect can vary due to genetic factors. The test allows you to determine how your body reacts to ASA and receive personalized recommendations for optimal prevention. This is because acetylsalicylic acid is often used in medical practice to prevent heart attacks and strokes.

The test makes it possible to better assess the risks of side effects such as gastrointestinal bleeding and to adjust the necessity or dosage of the medication in a targeted manner. This is because it analyzes specific genes that influence the metabolism of ASA and sensitivity to side effects.

Especially before starting antiplatelet therapy, this test is a valuable tool for developing a personalized treatment strategy.

After sending in your saliva sample, it undergoes a series of highly specialized processing steps in the laboratory. Here is a detailed overview of how the process works:

Week 1 – Sample preparation and DNA extraction

Once your sample has been received by the laboratory, it is registered and carefully checked for suitability. The DNA is then extracted from the saliva sample. To do this, the sample is purified and prepared for analysis in a multi-stage process.

Week 1-2 – Genetic analysis

Their extracted DNA will now be subjected to a detailed genetic analysis. Specialized genetic markers that are associated with the effect and tolerance of acetylsalicylic acid are examined. This is done using modern technologies such as polymerase chain reaction (PCR) and next-generation sequencing, which make it possible to precisely identify the smallest differences in your DNA. This step is crucial for the quality and significance of the results.

This precise, multi-stage laboratory process ensures that you receive a reliable and accurate result.

Week 2-3 – Preparation of your individual report

A comprehensive individual report is created based on the genetic data.

Week 3+ – Results announcement

Once the analysis has been completed and the report prepared, your personal ASS-100 gene report will be sent to you.