Resveratrol and Longevity: How the Plant Compound May Influence Lifespan

Resveratrol and longevity

Resveratrol is a polyphenol found in grapes, berries, peanuts and Japanese knotweed.

Why is it linked to longevity?

Resveratrol became famous through research on sirtuins and calorie-restriction-related pathways.

Cell and animal studies

Preclinical studies report effects on oxidative stress, inflammation, mitochondrial function and metabolism.

Some animal models show improved health or lifespan, while others do not.

Human evidence

Clinical studies have examined insulin sensitivity, blood pressure, blood lipids and inflammatory markers.

Results are inconsistent and depend on dose, population and formulation.

Bioavailability

Resveratrol is absorbed but rapidly metabolized. Blood concentrations of unchanged resveratrol remain relatively low.

Trans-resveratrol

The trans form is the most commonly studied and is generally considered more stable than the cis form.

Food or supplement?

Food provides small amounts alongside other polyphenols. Supplements provide much higher standardized doses.

Safety

Possible adverse effects include digestive discomfort and interactions with anticoagulants or other medication.

Conclusion

Resveratrol is an important research compound, but it is not a proven life-extending treatment in humans.