Longevity Guide – Health – Page 7

The microbiome is far more than just part of our digestive system. The countless microorganisms in the gut influence metabolism, the immune system, inflammatory processes, and even communication with organs such as the liver and brain. When this delicate balance is disrupted, it is known as dysbiosis, which has been associated with various chronic diseases. This article explains how a fibre-rich, predominantly plant-based diet can support the microbiome and why gut health also plays an important role in healthy aging and longevity.

Mitochondria supply our cells with energy and are therefore essential for the proper functioning of almost every organ in the body. In mitochondrial disease (mitochondriopathy), this energy metabolism is impaired, which can affect muscles, the nervous system, the eyes, and many other organs depending on the severity of the condition. This article explains the vital role of mitochondria, the symptoms that may occur in mitochondrial disorders, and why supporting cellular energy production has also become an important focus of longevity research.

Metabolism is closely linked to biological processes relevant to healthy aging, including mitochondrial function, insulin regulation, and cellular signaling pathways. What is important is less the lowest possible metabolic rate than the body's ability to regulate its energy balance and adapt to different requirements. Exercise, a balanced diet, sufficient sleep and the maintenance of muscle mass form an important basis for metabolic health, while calorie restriction and intermittent fasting are being studied but have no clearly proven life-extending effect in humans.

mTOR is considered one of the cell’s central control hubs, regulating key processes such as metabolism, cell growth, and cell division. In longevity research, this signaling pathway has attracted particular attention because targeted modulation of mTOR has been linked to aging, immune function, and the development of age-related diseases. This article explains why mTOR is important for healthy aging, how nutrient availability influences its activity, and why this pathway is regarded as a promising target for promoting long-term health and longevity.

Creatine is no longer considered a supplement solely for athletes. As an important energy reserve for the muscles and brain, it is increasingly gaining attention in the fields of healthy aging and longevity. This article explains why creatine monohydrate is regarded as the most extensively researched form, the role it may play in muscle strength, cognitive performance, cellular energy, and the preservation of muscle mass with age, and why quality and sustainable production are important factors when choosing a creatine product.

Calcium alpha-ketoglutarate combines calcium with AKG, a naturally occurring intermediate in energy metabolism that plays an important role in the mitochondria. This article explains why AKG levels decline with age and how CaAKG is being studied in relation to cellular energy, oxidative stress, inflammation, bone and muscle health, and biological age. Of particular interest is whether targeted supplementation can support cellular health and thereby contribute to healthy longevity.