ASS-100 Genetic Test
ASS-100 Genetic Test
ASS-100 Genetic Test
ASS-100 Genetic Test
ASS-100 Genetic Test
ASA GENES

    ASS-100 Genetic Test

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    How well can your body respond to ASA (acetylsalicylic acid)? The ASS-100 Genetic Test detects a selected genetic variant in the GUCY1A3 gene that has been associated in research with the effect of ASA on platelet aggregation and with cardiovascular events.

    • DNA test using a buccal swab for use at home

    • The sample is genetically analyzed in a German, ISO-certified laboratory

    • Determines the genotype of the GUCY1A3 variant rs7692387 in relation to the ASA response

    • Shows whether a typical or altered response to ASA is more likely to be expected

    • Preliminary medical consultation and structured ASS‑100 report

    CHF 142.00
    CHF 142.00
    Tax included. Shipping calculated at checkout.
    ASS-100 Genetic Test
    CHF 142.00
    CHF 142.00
    Delivered within 1–3 business days Free shipping

    Genetic variation in the GUCY1A3 gene: associated with the ASA response in studies.

    • DNA test using a buccal swab
      The ASS‑100 test kit is designed for straightforward sample collection at home. To perform the test, a buccal mucosa sample is placed in a sample tube, which is then sent to a specialized German laboratory certified according to ISO 9001:2015 and genetically analyzed there.
    • Determination of the genetic baseline for the ASA response
      The GUCY1A3 gene is involved in the regulation of platelet function and vascular processes and therefore influences how the body may respond to ASA. The variant examined in the test describes a personal genetic baseline for the ASA response. On this basis, it can be assessed whether, from a genetic perspective, a typical or an altered response to ASA is more likely to be expected.
    • Analysis of the GUCY1A3 variant rs7692387
      In the laboratory, defined DNA sections of the GUCY1A3 gene are examined in order to determine the genotype of the rs7692387 variant precisely. Because the respective genotype is genetically determined, a single analysis during a person’s lifetime is generally sufficient. The results classify the personal baseline in relation to platelet function influenced by ASA and can serve as a supplement for discussing the role of taking ASA in the individual context together with medical professionals.
    • Measuring for your own longevity routine
      Genetic variants do not change over the course of life and therefore form a stable basis for how the body responds to ASA. The test result shows whether the genetic baseline is more consistent with a typical ASA response or whether a particularly careful medical assessment of benefits and risks may be indicated.
    • Medical consultation and detailed report with classification
      Following the preliminary consultation, receipt of the sample and laboratory analysis, the ASS‑100 report is available after approximately 3 weeks. The report summarizes the result of the GUCY1A3 analysis in a structured manner, including gene function, individual genotype and a written classification in the context of the ASA response.
    Genetic variation in the GUCY1A3 gene: associated with the ASA response in studies.

    Understanding the ASS-100 Genetic Test

    Acetylsalicylic acid—ASA for short—is a well-established active substance from the group of nonsteroidal anti-inflammatory drugs (NSAIDs). In addition to its analgesic and anti-inflammatory effects, ASA is often used at low doses to prevent cardiovascular diseases.

    ASA inhibits the enzymes cyclooxygenase-1 and -2 (COX-1, COX-2), which are involved in the formation of thromboxane A₂. This inhibits the clumping of platelets and reduces the risk of blood clots.

    Whether and how ASA works is not the same in all people. This concerns both its effectiveness in blood thinning and the risk of side effects. Genetic differences—particularly in the GUCY1A3 gene—may influence this individual response.

    Particularly before taking ASA on a long-term basis—for example, for secondary prevention in the presence of an existing cardiovascular risk—it may be useful to take the individual genetic predisposition into account.

    With these findings, potential risks can be minimized and the therapy can be optimally tailored to your health needs in consultation with your treating physician.

    How does the ASS-100 Test work?

    1. Schritt

    Order your ASS‑100 Genetic Test and, following the preliminary consultation, receive your test kit at home within 1–3 working days. Then complete the enclosed documents.

    2. Schritt

    Use the swab to collect a buccal mucosa sample and place the swab in the sample tube. Place the sample tube and documents in the prepared return envelope and send it.

    3. Schritt

    The genetic variant rs7692387 in the GUCY1A3 gene is analyzed in a certified German laboratory. Your ASS‑100 report will be available after approximately 3 weeks.

    Scientific expertise
    “The ASS-100 Genetic Test enables a personalized assessment by analyzing genetic factors that may influence the individual response.”PD Dr. Axel Polack Lead Scientific Advisor · Founder

    FAQ

    We have the answers

    The ASS-100 Genetic Test is an at-home genetic test that you can perform conveniently after a preliminary consultation. You receive a test kit with detailed instructions and collect a buccal swab yourself. The sample is then sent to a specialist laboratory in Germany.

    The test is intended for adults aged 18 and over when long-term low-dose acetylsalicylic acid therapy is being considered for cardiovascular prevention or following an event such as a heart attack or stent implantation. During the preliminary consultation, you and your treating physician will determine whether the test is appropriate in your individual case.

    The test kits generally remain usable for several months. The exact best-before date is printed on the packaging. Store the kit in a dry place at room temperature until use and use it no later than the stated date to help ensure sample quality.

    The test kit contains everything required for sample collection: one or more swabs for collecting cells from the inside of the cheek, illustrated step-by-step instructions, labeling stickers and return packaging for shipment to the laboratory.

    The ASS test can be given as a gift, for example through our digital Longevity Card gift voucher. The recipient can then select and order the ASS test personally and manage the complete process independently. You can find the Longevity Card gift voucher in our shop.

    After the preliminary medical consultation, collect the buccal swab as described in the instructions. Rub the swab firmly against the inside of your cheek for the stated period, allow it to dry briefly and place it in the designated tube or transport sleeve. Package everything as instructed and send it to the laboratory using the enclosed return envelope.

    Follow the instructions supplied with the kit, particularly those concerning eating, drinking, smoking and brushing your teeth before sample collection. You should generally avoid eating, drinking and smoking for the stated period beforehand so that the buccal sample is not contaminated. Do not touch the swab with your fingers or other surfaces, and complete all labels fully and legibly.

    Yes. Intensive oral hygiene immediately before sample collection can affect the number of collected mucosal cells and may leave toothpaste or mouthwash residue in the sample. Therefore, do not brush your teeth, use mouthwash, eat, smoke or drink anything other than small amounts of water for at least 30–60 minutes before taking the buccal swab.

    Ideally, send your sample on the day of collection or the next working day, so that transport and storage times are kept as short as possible. If this is not possible, store the sealed sample at room temperature as instructed and send it within a few days. 

    Store the sealed sample in a dry place at room temperature, protected from direct sunlight and significant temperature fluctuations. Send it as soon as possible to help ensure optimal sample quality.

    The buccal swab can generally be collected at any time of day. Ideally, choose a time during your normal daily routine and avoid eating, drinking anything other than water, smoking or chewing gum for at least 30 minutes beforehand so that the sample remains as unaffected as possible.

    Because this is a genetic test, current medication does not alter the genetic variants being analyzed. However, your existing medication—especially acetylsalicylic acid and other anticoagulants—is important for medical interpretation and should be discussed fully during the preliminary consultation and review of the results.

    For returns from outside Germany, follow the enclosed shipping instructions. Allow for possible delays caused by customs procedures or longer transit times and send the sample as soon as possible after collection.

    Yes. You can collect the sample together with your physician if they are willing to assist you. However, the test remains an at-home test whose sample is sent to a specialist laboratory.

    The results report provides a clear summary of your genotype in the GUCY1A3 gene and classifies it into one of three possible categories: normal variant, heterozygous variant or risk variant.

    This allows you to see at a glance whether your genetic profile suggests a normal, potentially reduced or significantly altered response to acetylsalicylic acid.

    Click here to view an excerpt from a sample report.

    The ASS‑100 Genetic Test analyzes a genetic variant in the GUCY1A3 gene that, according to scientific studies, may be associated with the individual effect of acetylsalicylic acid (ASA). Three different genotypes may occur, each of which has a different relevance to the effectiveness of ASA: 

    ·      Homozygous for the “normal variant” (e.g. GG)
→ A normal response to ASA is likely. 

    ·      Heterozygous (e.g. GA)
 → A possibly reduced or altered response to ASA is possible. 

    ·      Homozygous for the risk variant (e.g. AA)
 → A clearly altered response to ASA is possible; close medical evaluation of the therapy may be indicated in this case. 

    The specific significance for your treatment—such as dose adjustments or alternative strategies—is always determined by your treating physician; the test serves as an additional basis for decision-making. 

    Once your sample has arrived at the laboratory, analysis usually takes around three weeks. As soon as the report is complete, you will be notified and can have the result interpreted as part of the medical review.

    Your genetic data are processed pseudonymously. This means that the laboratory works with a sample code rather than your name.

    Because this is a genetic test, the underlying hereditary information does not normally change over the course of life. An ASS‑100 Genetic Test that has been performed correctly once and can be evaluated therefore generally does not need to be repeated. Retesting may only be useful if there were formal reasons (e.g. a sample that could not be evaluated) or if your physician expressly recommends it for specific medical reasons. 

    A preliminary medical consultation is an integral part of the ASS‑100 Genetic Test and is mandatory for its performance. During this consultation, you and the physician clarify whether the test is suitable for your situation, which question is the primary focus and how a possible result will later be classified. 

    The consultation is currently conducted in German. Additional languages may be offered in the future; please contact us if you have a specific language requirement.

    An additional medical consultation after the result is not included as standard. However, you can discuss your result with your treating physician or book a separate longevity consultation, during which your findings can be explained in detail and possible next steps discussed.

    You can book an additional longevity consultation if desired. During the consultation, the genetic test results are placed in the broader context of cardiovascular risk, lifestyle and long-term health strategy, so that not only the ASA question but also your overall prevention and longevity profile can be addressed.

    Yes, you can also discuss the genetic findings with your treating cardiologist or your general practitioner. The combination of the genetic result and clinical assessment enables the best possible individual decision regarding the use of ASS‑100. 

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